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Thioaptamer Binding Performance Data<= /div>
Biacore and Atacti= c, Inc. Microfluidics Chip Results for
XBY-6 = to NFkB p50:p50 Dimer
May 2007
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www.= thioaptamer.com
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Biacore= Test Data for XBY-6 to NFkB Protein
Binding of NFkB p50:p50 to dsXBY6-biotin on Streptavidin Biacore Chip
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www.= thioaptamer.com
3
Biacore= Test Data for XBY-6 to NFkB Protein
Calculation of k(assoc.) Using Two Curves
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www.= thioaptamer.com
4
Biacore= Test Data for XBY-6 to NFkB Protein
Calculation of k(dissociation) Using Two Curves
Notice the long duration of = binding.
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www.= thioaptamer.com
5
Biacore= Test Data for XBY-6 to NFkB Protein
Dithioates Reversed Specificity (in this case) and Enhanced Affinity
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www.= thioaptamer.com
6
Atactic, Inc. Microfluidics Chip Test Data
The binding of natural sequences (i.e. no = = PS2 linkages) are <= /span>generally weak.
The affinity of PS2 oligos to proteins = is sequence = selective.
Dithioates enhance binding 100-300 fold.
Photograph of partial chip data.=
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