AMBiotech | Products



	Thioaptamers Thioaptamers are affinity agents that are developed for our customers using phosphorodithioate (PS2) DNA and the bead-based selection process • High affinity and selectivity to your protein, peptide, carbohydrate, or other small molecule • PS2 substitutions increase affinity and nuclease resistance without sacrificing specificity • Virtually any chemically-modified nucleotide can be used during selection • Microgram to multiple milligram quantities • Fully characterized for specificity and affinity • Applications: binding or capture agents; diagnostics; therapeutics • Features: selectivity and high binding affinity, nuclease resistance, achiral structure Thiophosphoramidites Thiophosphoramidites are unique reagents that are used to replace the two non-bridging oxygen atoms with sulfur atoms in a DNA or RNA phosphodiester linkage creating a phosphorodithioate (PS2) linkage. AM sells these reagents through Glen Research • Like natural DNA (RNA), the phosphorodithioate linkage is achiral at phosphorus • Eliminates stereoisomer formation associated with monothioate (PS) backbones • PS2 analog is completely resistant to nuclease degradation • PS2-ODNs bind proteins with a higher affinity than their phosphodiester analogues • PS2 siRNA enhance gene silencing and increase RNA in vivo stability