Thioaptamers are affinity agents that are developed for our customers using phosphorodithioate (PS2) DNA and the bead-based selection process.
• High affinity and selectivity to your protein, peptide, carbohydrate, or other small molecule
• PS2 substitutions increase affinity and nuclease resistance without sacrificing specificity
• Virtually any chemically-modified nucleotide can be used during selection
• Microgram to multiple milligram quantities
• Fully characterized for specificity and affinity
• Applications: binding or capture agents; diagnostics; therapeutics
• Features: selectivity and high binding affinity, nuclease resistance, achiral structure
Thioaptamer Comparison to Monoclonal Antibodies
| Important Considerations |
Antibodies |
Thioaptamers |
| Target Range |
Limited to those targets that cause an antibody response in animals |
Nearly unlimited: includes proteins, cells, bacteria, viruses, small molecules, carbohydrates, and lipids |
| Development Time |
Months |
Weeks |
| Production |
Initially produced in animals
Difficult to control quality
Expensive bioreactors needed |
Easy chemical synthesis
Excellent quality control
Established contract manufacturers |
| Storage / Handling |
Must be refrigerated and/or frozen
Denature easily |
Ambient environment stability
No refrigeration or freezing needed |
| Shelf Life |
Limited |
Greatly extended |
| In vivo Effects |
Can cause a severe inherent immune response when used as a drug |
No inherent immune response |
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