Contract Thioaptamer Discovery

AM Biotechnologies can discover thioaptamers for you.

• Identify the sequence and dithioate backbone modifications that provide the best performance characteristics for customer-selected targets
  • Customer provides the target (amount varies) and information regarding special requirements
  • AM will select the sequence and backbone modifications that best meet customer requirements
  • AM will test the best sequences and dithioate modifications that were discovered and deliver a small quantity of thioaptamer along with the sequence/modification information
  • Typically, the customer owns the intellectual property of the discovered thioaptamer; however, AM will discuss other arrangements if desired
• Convert aptamers to thioaptamers (dithioated oligonucleotides)
  • Improve nuclease resistance
  • Enhance binding affinity
  • Make achiral

 

Oligonucleotide Production

AM Biotechnologies will synthesize and purify small quanties (milligrams) of dithioate or other oligos. Larger quantities are available through our partner The Oligo Factory. 

 

Contact AM for more information. 

 

Contract Reagent Development

AM Biotechnologies chemists have world class expertise in nucleic acid chemistry and especially in sulfur-related modifications.  If you have a need to develop special reagents, contact AM for more information.

• Modified thiophosphoramidites
• RNA
• Linker chemistries
• 5' or 3' functionalized or modified oligos
• Others