Thioaptamer
 
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Thiophosphoramidites can substantially improve the performance of an oligonucleotide.  Use these reagents along with standard phosphoramidite and sulfurization reagents to create dithio modifications at several oligo sequence locations.  (AM recommends substituting between 10% and 30% of the standard bases with dithio modifications to achieve the best overall performance.)  The dithio substitutions typically result in an oligo that exhibits:

      • Greater stability
      • Greater affinity
      • More nuclease resistance
      • Achiral molecular structure

 

Purchase Thiophosphoramidites through our partner Glen Research.

 dA

5' -Dimethoxytrityl-N-benzoyl-2’-deoxy-Adenosine, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)], M.W.: 959.7
 

 dC

5’-Dimethoxytrityl-N-benzoyl-2’-deoxy-Cytidine, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)], M.W.: 950.7
 

 dG      

5’-Dimethoxytrityl-N-isobutyryl-2’-deoxy-Guanosine, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)], M.W.: 936.7
 

 T

5’-Dimethoxytrityl-2’-deoxy-Thymidine, 3'-[(β-thiobenzoylethyl)-(1-pyrrolidinyl)], M.W.: 841.6

Thiophosphoramidites are sold for research purposes only. 

Contact AM Biotechnologies to discuss other applications.


 
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